Open NIH SBIR/STTR topics — May 2026
Every open NIH SBIR/STTR solicitation we tracked across SAM.gov, SBIR.gov, and Grants.gov this week. Newest first. ITAR/CUI-restricted topics dropped automatically.
Paste a one-paragraph capability statement at /try — TopicScout ranks the open SBIR/STTR topics that actually fit and shows you the rationale per match. No signup, no card.
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Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2027-10-19
This Notice of Funding Opportunity (NOFO) solicits applications for the development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and…
→ Full topic / applySustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-10-19
This Notice of Funding Opportunity (NOFO) solicits applications for the continued development and sustainment of high value informatics research resources to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer…
→ Full topic / applyAdvanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-10-19
This Notice of Funding Opportunity (NOFO) invites applications for advanced development and enhancement of emerging informatics technologies to improve the acquisition, analysis, visualization, and interpretation of data across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment…
→ Full topic / applyEstablishing a Center for the Advancement of Substance Use Disorder (SUD) Pharmacotherapeutics through Training and Preclinical Support (U54 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-09-30
The purpose of this notice of funding opportunity (NOFO) is to establish a Center that trains researchers in formal product development for new substance use disorder (SUD) pharmacotherapeutics and to advance the best concepts through initial experiments via technical and financial support.
→ Full topic / applyNCI Community Oncology Research Program (NCORP) Community Sites (UG1 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-09-18
This Notice of Funding Opportunity (NOFO) is one of three NOFOs for the National Cancer Institute (NCI) Community Oncology Research Program (NCORP). NCORP is designed to enhance generalizability and dissemination of clinical trial and other human subject research study results through accrual in a variety of community settings. The purpose of NCORP is to…
→ Full topic / applyNCI Community Oncology Research Program (NCORP) Research Bases (UG1 Clinical Trial Required)
National Institutes of Health (HHS-NIH11) · closes 2026-09-18
This Notice of Funding Opportunity (NOFO) is one of three NOFOs for the National Cancer Institute (NCI) Community Oncology Research Program (NCORP). NCORP is designed to enhance generalizability and dissemination of clinical trial and other human subject research study results through accrual in a variety of community settings. The purpose of NCORP is to…
→ Full topic / applyNCI Community Oncology Research Program (NCORP) Academic Community Sites (UG1 Clinical Trials Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-09-18
This Notice of Funding Opportunity (NOFO) is one of three NOFOs for the National Cancer Institute (NCI) Community Oncology Research Program (NCORP). NCORP is designed to enhance generalizability and dissemination of clinical trial and other human subject research study results through accrual in a variety of community settings. The purpose of NCORP is to…
→ Full topic / applyTransformative Non-Invasive/Minimally Invasive Technologies for Imaging the Olfactory System Across Scales (R01 CT Optional)
National Institutes of Health (HHS-NIH11) · closes 2028-08-21
The National Institute on Deafness and Other Communication Disorders (NIDCD), with the National Institute of Biomedical Imaging and Bioengineering (NIBIB) aims to support the development and/or adaptation of transformative in vivo high-resolution/high specificity imaging of the human olfactory system. Currently, there are limited non-invasive/minimally…
→ Full topic / applySingle Source for Continuation of the Integrated Islet Distribution Program U24 (Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-09-30
This is a NOFO for a Single Source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.The National…
→ Full topic / applyKidney, Urologic, and Hematologic Diseases - Fostering the AdvanceMent of an Interactive Learning communitY - Coordinating Center (KUH-FAMILY) (U24- Clinical Trials Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-01
The Division of Kidney, Urologic, and Hematologic Diseases (KUH) at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) currently supports several institutional and individual training and career development programs. The purpose of this Notice of Funding Opportunity (NOFO) is to establish a single Coordinating Center to unite…
→ Full topic / applyUsing Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 CT Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2028-10-20
The purpose of this Funding Opportunity is to address the needs of the maternal and pediatric HIV scientific community for research data translation and sharing.This initiative will support secondary data analyses using archived HIV/AIDS data and specimens. The goal of this initiative is to encourage the scientific community to utilize HIV/AIDS archived…
→ Full topic / applyLimited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2028-09-25
The National Institute of Environmental Health Sciences (NIEHS) is announcing the continuation of the Superfund Hazardous Substance Research and Training Program, referred to as Superfund Research Program (SRP) Centers. SRP Center grants will support problem-based, solution-oriented research Centers that consist of multiple, integrated projects…
→ Full topic / applyHEAL INITIATIVE: INTERACT Data Coordination and Integration Center (U24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-10-01
This notice of funding opportunity (NOFO) invites applications from eligible organizations to establish a Data Coordination and Integration Center (DCIC) for the NIH HEAL Initiative. This Center will support the coordination and integration of data from both the HEAL INTERACT program and progressively facilitate broader integration of related…
→ Full topic / applyHeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Clinical Trial Center and Clinical Centers (U01 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-07-09
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for a new Clinical Trial Center (CTC) and up to seven Clinical Centers (CCs) for the HeartShare 2.0 program. The CTC will coordinate precision clinical trial activities focused on heart failure with preserved ejection fraction (HFpEF), including master protocol…
→ Full topic / applySingle Source: HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Data Translation Center (U54 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-07-09
This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invites an application from an eligible organization to apply. Please see Section III. Eligibility for additional information. The NHLBI is announcing its intent to issue a single source cooperative agreement to Northwestern University. This NOFO solicits a renewal of the Data…
→ Full topic / applyLimited Competition: Intellectual and Developmental Disabilities Research Centers 2027 (P50 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-10-02
This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. The purpose of this NOFO is to seek applications in a limited competition for the Eunice Kennedy Shriver Intellectual and Developmental…
→ Full topic / applyINCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)
National Institutes of Health (HHS-NIH11) · closes 2028-06-15
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) encourages Exploratory/Developmental Phased Innovation (R61/R33) grant applications to support…
→ Full topic / applyMaximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI)
National Institutes of Health (HHS-NIH11) · closes 2029-02-06
The Maximizing Investigators' Research Award (MIRA) for Early Stage Investigators (ESIs) provides support for ESIs with a program of research that aligns with the NIGMS mission.MIRA distributes funding among promising investigators across the country. The goal is to boost scientific productivity and the chances for important breakthroughs.Through…
→ Full topic / applyLimited Competition: Small Grant Program for NHLBI K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2028-11-07
This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that invites applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered. The…
→ Full topic / applyINCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2028-06-15
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that…
→ Full topic / applyINCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2028-06-15
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of…
→ Full topic / applyThe Experimental Therapeutics Clinical Trials Network (ETCTN) Lead Academic Organizations (UM1 Clinical Trial Required)
National Institutes of Health (HHS-NIH11) · closes 2026-06-30
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications from institutions/organizations that propose to maintain or establish Lead Academic Organizations (LAOs) as part of the NCI Experimental Therapeutics Clinical Trials Network (ETCTN). ETCTN LAOs will design, develop, monitor, conduct, and analyze…
→ Full topic / applyThe Experimental Therapeutics Clinical Trials Network (ETCTN) Pharmacokinetic Resource Laboratory (U24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-06-30
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications from institutions/organizations that propose to maintain or establish a Pharmacokinetics Resource Laboratory (PK Laboratory) to support the Experimental Therapeutics Clinical Trials Network (ETCTN). The PK Laboratory will organize biospecimen…
→ Full topic / applyNIAID Resource-Related Research Projects (R24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-05-25
This notice of funding opportunity (NOFO) invites applications for investigator-initiated Resource-Related Research Projects (R24). The proposed resource must provide a significant benefit to currently funded high priority projects in need of further coordination and support in the areas specified. This mechanism may also be used to support development…
→ Full topic / applyNIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-05-25
This notice of funding opportunity (NOFO) invites submission of investigator-initiated Program Project (P01) applications. The proposed Programs should address scientific areas relevant to the NIAID mission including: biology and pathogenesis of infectious microbes, including HIV; host-microbe interactions; mechanisms regulating immune system development…
→ Full topic / applyNew Generation of Glucose Control Technologies Incorporating AI/ML Tools/Strategies (R01 - Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-06-17
The purpose of this funding opportunity is to support research addressing barriers that limit progress toward more effective open- and closed-loop diabetes control systems. This may include research that addresses: 1) innovation of sensing relevant analytes/physiologic signals; 2) novel formulation and delivery of hormones; 3) artificial intelligence…
→ Full topic / applySingle Source: Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Data Processing, Analysis, and Coordination Center (DPACC) (U24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-06-09
NIMH is announcing its intent to issue a single source cooperative agreement award to Brigham and Women"s Hospital to support continuation of the AMP® SCZ Data Processing, Analysis, and Coordination Center (DPACC). This allows DPACC to complete the processing and analysis of longitudinal multi-modal biomarker and clinical outcome data collected…
→ Full topic / applyNIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-05-25
The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this NIH Science Education Partnership Award (SEPA) program is to support educational activities that increase understanding of biomedical research among pre-college (pre-kindergarten to grade12) individuals, and to…
→ Full topic / applyResearch Opportunities in Cancer Epidemiology Cohort Studies (U01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-07-05
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) encourages grant applications to support research in cancer epidemiology cohort studies that address specific knowledge gaps in cancer etiology and survivorship. Applications should include hypothesis-based research, support for cohort infrastructure and/or…
→ Full topic / applyBioengineering Research Grants (BRG) (R01 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2029-07-05
This Notice of Funding Opportunity (NOFO) encourages collaborations between the life and physical sciences that: 1) apply a multidisciplinary bioengineering approach to the solution of a biomedical problem; and 2) integrate, optimize, validate, translate or otherwise accelerate the adoption of promising tools, methods, and techniques for a specific…
→ Full topic / applyCCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2028-11-05
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit basic research applications to investigate the pathological mechanisms of skin injuries caused by toxic Chemicals of Concern (CoC) identified as public health threats by the United States Government. This NOFO supports the goal of the trans-NIH Chemical Countermeasures Research…
→ Full topic / applyDiscovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2027-03-05
The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new…
→ Full topic / applyBRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2027-02-11
Invasive surgical procedures in humans offer the unique opportunity to intracranially record and stimulate neuronal activity within precisely localized brain structures, enabling high-impact human neuroscience investigations. This NOFO seeks exploratory research projects, from newly formed or established multi-disciplinary teams, to understand how…
→ Full topic / applyAmyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
National Institutes of Health (HHS-NIH11) · closes 2026-11-10
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for the conduct of scientific research utilizing data from expanded access (EA) for investigational drugs or biological products as described in section 561 of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 360bbb). These applications will target intermediate size…
→ Full topic / applyAccelerating Product Excellence in Innovation and for Clinical Adoption (APEx) (U24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-10
This Notice of Funding Opportunity (NOFO) solicits cooperative agreement research applications to support a multidisciplinary program titled "Accelerating Product Excellence in Innovation and for Clinical Adoption" (APEx), that will facilitate advancement of promising strategies and products for tissue engineering and regenerative medicine…
→ Full topic / applyTuberculosis Research Advancement Centers (TRACs) (P30 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-10
The purpose of this notice of funding opportunity (NOFO) is to support applications for the Tuberculosis (TB) Research Advancement Centers (TRACs) program. The goal of the TRACs is to develop the next generation of TB researchers and to catalyze multidisciplinary and innovative TB science by providing expertise and resources to facilitate basic and…
→ Full topic / applyCoccidioidomycosis Collaborative Research Centers (P01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-09
The purpose of the notice of funding opportunity (NOFO) is to solicit applications for a Coccidioidomycosis Collaborative Research Centers (CCRC) program. This new initiative will establish highly collaborative, multi-disciplinary, research teams to conduct translational and clinical research to support the development of a Valley fever vaccine as…
→ Full topic / applyAddressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required)
National Institutes of Health (HHS-NIH11) · closes 2026-10-11
The purpose of this notice of funding opportunity (NOFO) is to elucidate the key components of the therapeutic effects of rapid-acting psychotropic interventional drugs (RAPIDs) by addressing the methodological challenges involved with these clinical trials. In addition, this NOFO seeks to advance understanding of how RAPIDs and adjunctive psychosocial…
→ Full topic / applyCommunity-Based Participatory Research to Advance Data and Practice Transformation (ADAPT) for Optimizing Oral Health for All (UG3/UH3 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2028-11-16
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit UG3/UH3 phased, cooperative agreement research applications to evaluate, implement, and/or test population-based interventions to policies, programs, and/or practices for promoting integration of services, systems, and/or values by leveraging cross-sector partnerships in communities.…
→ Full topic / applyCommunity Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-10-19
The purpose of this Notice of Funding Opportunity (NOFO) is to seek applications for a Community Engagement Evaluation and Data coordination hub (CEED) for the Community-Based Participatory Research (CBPR) consortium: Advancing Data and Practice Transformation (ADAPT) for Optimizing Oral Health for All. In addition to CEED, the ADAPT consortium will…
→ Full topic / applyPaste a one-paragraph capability statement at /try — TopicScout ranks the open SBIR/STTR topics that actually fit and shows you the rationale per match. No signup, no card.
Try the live matcher →