Open NIH SBIR/STTR topics — June 2026
Every open NIH SBIR/STTR solicitation we tracked across SAM.gov, SBIR.gov, and Grants.gov this week. Newest first. ITAR/CUI-restricted topics dropped automatically.
Paste a one-paragraph capability statement at /try — TopicScout ranks the open SBIR/STTR topics that actually fit and shows you the rationale per match. No signup, no card.
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Renewal of the Clinician-Scientists Transdisciplinary Aging Research (Clin-STAR) Coordinating Center (U24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-09-29
The purpose of this Notice of Funding Opportunity (NOFO) is to support the next 5-year award period of the Clinician-Scientist Transdisciplinary Aging Research Coordinating Center (Clin-STAR CC), whose mission is to serve as a national resource for clinician-investigators across specialties and disciplines who are focusing their careers on aging…
→ Full topic / applyNIH Director’s Early Independence Award (DP5 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-09-10
The NIH Director's Early Independence Award helps talented new researchers begin their own independent research program soon after finishing their doctoral degree or clinical training, without first doing postdoctoral training.The award accepts applications on any topic fitting the NIH mission. It is part of the NIH Common Fund's High-Risk,…
→ Full topic / applyNIH Director’s New Innovator Award (DP2 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-08-17
The NIH Director"s New Innovator Award supports early-stage investigators of exceptional creativity who propose bold and highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to the mission of NIH. Applications in any area within the biomedical sciences are welcome; topics may involve…
→ Full topic / applyShared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2028-07-01
This Notice of Funding Opportunity (NOFO) announces the restructured Shared Instrumentation Grant (SIG) Program that consolidates three existing shared-use instrumentation programs, i.e., the Shared Instrumentation Grant program, the High-End Instrumentation Grant program, and the Basic Instrumentation Grant program. The NOFO invites applications from…
→ Full topic / applySeed Instrumentation Support (SIS) Program (S10 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2028-07-01
This Notice of Funding Opportunity (NOFO) aims to build new research capacity and develop a sustainable research program by supporting the purchase of a single commercially available biomedical research instrument currently unavailable in the institution. Instruments funded through this program must be shared among the users to create new research…
→ Full topic / applyLimited Competition: Growing Great Ideas: Research Education Course in Entrepreneurship and Product Development for Researchers Studying Drug Use, Drug Misuse, and Drug Addiction (UE5 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-10-01
This notice of funding opportunity (NOFO) seeks to establish a course to equip researchers studying drug use, drug misuse, and drug addiction with the skills, knowledge, and practical tools needed to translate their scientific discoveries into impactful real world solutions. The course is envisioned to focus on building capacity in product development,…
→ Full topic / applyInstitutional Mentored Career Development Award (Parent K12) (Clinical Trials Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-07-12
The National Institutes of Health (NIH) will award Institutional Mentored Career Development grants to eligible domestic institutions to support career development programs designed to prepare later stage postdoctoral fellows and junior faculty scholars who have made a commitment to an independent research career for their career advancement and…
→ Full topic / applyLimited Competition: Centers of Biomedical Research Excellence: Expansion/Sustainability Phases (COBRE-E/S) (P30 - Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-05-25
The Institutional Development Award (IDeA) program supports biomedical research capacity building in states that have historically received low levels of NIH funding. The Centers of Biomedical Research Excellence: Expansion/Sustainability Phases (COBRE-E/S) Notice of Funding Opportunity (NOFO) supports the expansion and sustainability of biomedical…
→ Full topic / applyGREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-10-30
The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. The purpose of this Notice of…
→ Full topic / applyGREGoRi Technology Integration Center (U01, Clinical Trials Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-10-30
The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. The purpose of this Notice of…
→ Full topic / applyGREGoRi Innovation Projects (U01 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-10-30
The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding…
→ Full topic / applyNIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)
National Institutes of Health (HHS-NIH11) · closes 2029-07-05
This notice of funding opportunity (NOFO) encourages applications for implementation of investigator-initiated, milestone driven clinical trials that need enhanced oversight, and as applicable, include mechanistic studies. Mechanistic work in clinical trials may be of great value because it promotes the understanding of human diseases and the development…
→ Full topic / applyNIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-07-05
This Notice of Funding Opportunity (NOFO) will support, through the cooperative agreement mechanism, investigator-initiated observational studies or biomarker validation studies that require prospective collection of data/biospecimens or continued analysis of data/biospecimens.
→ Full topic / applyPredoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-04-08
The purpose of this award is to support promising graduate students as they complete their doctoral research training and transition into mentored postdoctoral career development opportunities in research areas relevant to the missions of participating NIH Institutes and Centers.This Notice of Funding Opportunity (NOFO) does not allow candidates to…
→ Full topic / applyHEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2029-02-20
The purpose of this Notice of Funding Opportunity (NOFO) is to support the preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics for the treatment of pain. The goal of the program is to accelerate the advancement of promising early-stage therapeutic candidates and facilitate their…
→ Full topic / applySilvio O. Conte Digestive Diseases Research Core Centers (P30-Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2027-02-10
This Notice of Funding Opportunity (NOFO) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK. The purpose of this Centers program is to bring together basic and clinical investigators to enhance…
→ Full topic / applyHEAL Initiative: Limited Competition for the HEALthy Brain and Child Development Study - Research Project Sites (Collaborative U01- Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-10
This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility, for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered…
→ Full topic / applyHEAL Initiative: Limited Competition for the HEALthy Brain and Child Development (HBCD) Study – Consortium Administrative Core and Data Coordinating Center (U24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-10
This is a Notice of Funding Opportunity (NOFO) is for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility, for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered…
→ Full topic / applyScience Track Award for Research Transition (START) Program (R03, Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2029-03-16
The purpose of this notice of funding opportunity (NOFO) is to facilitate the entry of investigators into multiple high-priority areas of substance use research, including comorbidity with HIV. The Science Track Award for Research Transition (START) Program aims to provide investigators with the opportunity to gather preliminary data that will assist…
→ Full topic / applyAvant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2028-09-25
The purpose of this notice of funding opportunity (NOFO) is to support innovative basic, clinical, translational, and implementation science research relevant to HIV and substance use. This initiative encourages high risk high impact transformative studies that advance knowledge and strategies for HIV prevention, diagnosis, treatment and virus…
→ Full topic / applyNIH Research Education Program - Courses, Curriculum & Methods (Parent R25 - Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-05-25
The National Institutes of Health (NIH) Research Education Program supports research education activities in the mission areas of the NIH. The overarching goal of the Research Education program is to:Support educational activities that complement and/or enhance training of a workforce to meet the nation's biomedical, behavioral and clinical research…
→ Full topic / applyNIH Research Education Program - Research Experiences (Parent R25 - Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-05-05
The National Institutes of Health (NIH) Research Education Program supports research education activities in the mission areas of the NIH. The overarching goal of the Research Education program is to:Support educational activities that complement and/or enhance training of a workforce to meet the nation's biomedical, behavioral and clinical research…
→ Full topic / applyNIH Research Educational Program - Mentoring Activities & Networks (Parent R25/UE5 - Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-05-05
The National Institutes of Health (NIH) Research Education Program supports research education activities in the mission areas of the NIH. The overarching goal of the Research Education program is to:Support educational activities that complement and/or enhance training of a workforce to meet the nation's biomedical, behavioral and clinical research…
→ Full topic / applyBiomedical Technology Optimization and Dissemination Center (BTOD) (RM1 - Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-01-29
This Notice of Funding Opportunity (NOFO) encourages applications for NIGMS Biomedical Technology Optimization and Dissemination (BTOD) Centers to support late-stage technology optimization and sustainable dissemination of the technologies to the wider biomedical research community. A BTOD Center should be at the leading edge of its field with respect to…
→ Full topic / applyOptimal Treatment Strategies for use of Anti-Obesity Medications (AOMs) in Children and Adolescents Clinical Centers (U01 Clinical Trial Required)
National Institutes of Health (HHS-NIH11) · closes 2026-10-09
This Notice of Funding Opportunity (NOFO) invites applications from clinical centers to participate in a consortium to test anti-obesity medication (AOM) treatment strategies for youth with obesity that maximize benefits and minimize risks of AOM use. Such intervention strategies should support the promotion of healthy growth and development; adequate…
→ Full topic / applyOptimal Treatment Strategies for use of Anti-Obesity Medications (AOMs) in Children and Adolescents Research Coordinating Center (U24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-10-09
This Notice of Funding Opportunity (NOFO) invites applications for a Research Coordinating Center (RCC) to participate in a consortium of clinical centers that will test anti-obesity medication (AOM) treatment strategies for youth with obesity that maximize benefits and minimize risks of AOM use. Such intervention strategies should support the promotion…
→ Full topic / applyLimited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study-Research Project Sites (U01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-09
This is a notice of funding opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with the National Institutes of Health (NIH) standard peer-review processes, the applications will be peer-reviewed, and only meritorious…
→ Full topic / applyLimited Competition for the Adolescent Brain Cognitive Development -Extended (ABCD-E) Study Renewal - Data Analysis, Informatics and Resource Center, and Coordinating Center (U24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-09
This is a notice of funding opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility for additional information. In accordance with the National Institutes of Health (NIH) standard peer-review processes, the applications will be peer-reviewed, and only meritorious…
→ Full topic / applyCausal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-07-05
This Notice of Funding Opportunity (NOFO) invites applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial,…
→ Full topic / applyHEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2029-02-09
The goal of this notice of funding opportunity (NOFO) is to address the opioid crisis and/or overdose events by supporting action-oriented research, accelerating the translation of addiction epidemiology, prevention, treatment services, and recovery research to practice. Proposed studies may target the individual, provider, organizational, community, or…
→ Full topic / applyContinuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2027-03-10
The NIH Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) was created to improve research on type 1 diabetes (T1D) and cardiovascular disease (CVD). Cardiovascular complications remain the top cause of death among people with T1D and greatly shorten lifespan. The mechanisms underlying atherosclerosis, cardiomyopathy, endothelial dysfunction, and…
→ Full topic / applySingle Source Competition: Continuation of the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) - Resource Center (U24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-09-30
This Notice of Funding Opportunity (NOFO) invites a single cooperative agreement application for the Resource Center for the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D). The purpose of CaRe-T1D is to support innovative, discovery and mechanistic research through the study of human cardiovascular (CV) tissue. This research seeks to better…
→ Full topic / applyMetastasis Research Network (U54 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-09-25
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on developing a comprehensive and cohesive understanding of cancer metastasis. Towards this goal, the NCI will support U54 Specialized Centers that together will continue to serve as the hub of the Metastasis Research Network…
→ Full topic / applyPaul Calabresi Career Development Award for Clinical Oncology (K12 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2029-03-12
The goal of the Paul Calabresi Career Development Award for Clinical Oncology (PCACO) is to increase the number of clinician-scientists trained in clinical and translational cancer research, and to promote their career development as cancer researchers. This Notice of Funding Opportunity (NOFO) does not allow Scholars to propose to lead an independent…
→ Full topic / applyAdvanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-11-10
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites grant applications proposing exploratory research projects focused on further development and technical validation of emerging technologies offering novel capabilities for the molecular or cellular characterization of cancer or for improved handling and quality…
→ Full topic / applyEarly-Stage Innovative Technology Development for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-11-10
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits grant applications proposing to develop innovative technologies offering new capabilities for the molecular or cellular characterization of cancer or for improved handling and quality control of biospecimens for basic, clinical, or epidemiological cancer…
→ Full topic / applyNovel Experiential Technologies Assisting Individual Learning (NExT AI) Hubs (P20 Clinical Trial Optional)
National Institutes of Health (HHS-NIH11) · closes 2026-10-02
This Notice of Funding Opportunity (NOFO) invites exploratory grant applications, hereafter referred to as the Novel Experiential Technologies Assisting Individual learning Hubs or NExT AI Hubs (formerly Learning Disabilities Innovation Hubs), to address the impact of Artificial Intelligence (AI) technologies on developmental outcomes in children…
→ Full topic / applyKidney Precision Medicine Project Recruitment Sites (U01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-10
This Notice of Funding Opportunity (NOFO) requests applications for Kidney Precision Medicine Project (KPMP) Recruitment Sites (RS) to enroll people with Acute Kidney Injuries (AKI) and/or Chronic Kidney Diseases (CKD) into a longitudinal biopsy cohort study. Under-enrolled populations (e.g., AKI) and comprehensive phenotyping remain priorities. New…
→ Full topic / applyKidney Precision Medicine Project Tissue Interrogation Sites (U01 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-10
This Notice of Funding Opportunity (NOFO) requests applications for Kidney Precision Medicine Project (KPMP) Tissue Interrogation Sites (TIS) to use highly integrated multi-modal analytic pipelines to interrogate human kidney biopsy tissue to discover and define new disease pathways and subgroups that enable precision clinical trials. All KPMP personnel…
→ Full topic / applyKidney Precision Medicine Project Central Hub (U24 Clinical Trial Not Allowed)
National Institutes of Health (HHS-NIH11) · closes 2026-07-10
This Notice of Funding Opportunity (NOFO) requests applications for the Kidney Precision Medicine Project (KPMP) Central Hub (CH) to lead a unified effort to discover and define new acute and chronic kidney disease pathways and subgroups that enable precision clinical trials. The CH will provide strategic leadership for the entire KPMP and steward…
→ Full topic / applyPaste a one-paragraph capability statement at /try — TopicScout ranks the open SBIR/STTR topics that actually fit and shows you the rationale per match. No signup, no card.
Try the live matcher →