SBIR & STTR Topics for Sensors & IoT Companies in Colorado

There are 15 open federal SBIR/STTR topics right now that match Sensors & IoT capabilities, across DOD, NIH, NSF, DOE, NASA, USDA, and 5 other agencies. Below: the current open topic list, recent Sensors & IoT winners headquartered in Colorado, the Colorado SBDC SBIR contact, and how TopicScout compares to SBIR.gov / Grants.gov / HigherGov / Instrumentl for finding the next topic to apply to.

Open Sensors & IoT topics (15)

1. Antarctic Research Not Requiring U.S. Antarctic Program (USAP) Field Support — U.S. National Science Foundation · closes 2026-06-01
   Through this solicitation, the Antarctic Sciences Section (ANT) of the Office of Polar Programs (OPP) funds cutting-edge research that: Improves understanding of interactions among the Antarctic region and global systems. Improves understan…
2. Antarctic Research Requiring U.S. Antarctic Program (USAP) Support for Fieldwork — U.S. National Science Foundation · closes 2026-06-01
   Through this solicitation, the Antarctic Sciences Section (ANT) of the Office of Polar Programs (OPP) funds cutting-edge research that requires logistical support from the U.S. Antarctic Program (USAP)and: Improves understanding of interact…
3. Preclinical Proof of Concept Studies for Rare Diseases (R21 Clinical Trial Not Allowed) — National Institutes of Health · closes 2026-06-02
   This notice of funding opportunity (NOFO) provides funding to conduct efficacy studies in an established rare disease preclinical model to demonstrate that a proposed therapeutic agent warrants further development. In addition to preclinica…
4. Alfalfa Seed and Alfalfa Forage Systems — National Institute of Food and Agriculture · closes 2026-06-12
   In FY 2026, under Assistance Listing 10.330, ASAFS will support the development of improved alfalfa seed and forage production systems, practices, and supporting technologies. NIFA is soliciting applications for FY 2026 under the following …
5. Single Source: Cardiothoracic Surgical Trials Network (CTSN) Data Coordinating Center (U01 Clinical Trial Required) — National Institutes of Health · closes 2026-07-07
   This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from the eligible organization to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer…
6. Accelerating Product Excellence in Innovation and for Clinical Adoption (APEx) (U24 Clinical Trial Not Allowed) — National Institutes of Health · closes 2026-07-10
   This Notice of Funding Opportunity (NOFO) solicits cooperative agreement research applications to support a multidisciplinary program titled "Accelerating Product Excellence in Innovation and for Clinical Adoption" (APEx), that wi…
7. Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required) — National Institutes of Health · closes 2026-07-14
   This Notice of Funding Opportunity (NOFO) encourages cooperative agreement applications for investigator-initiated, multi-site, clinical trials (Phase III and beyond) to study the effects of natural products (i.e. botanicals, probiotics, an…
8. FY 2026 Ocean Technology Transition Program — DOC NOAA - ERA Production · closes 2026-07-15
   Request for Applications Description: The U.S. Integrated Ocean Observing System (IOOS®) is a national and regional partnership working to provide ocean, coastal and Great Lakes observations, data, tools, and forecasts to improve safet…
9. ECosystem for Leading Innovation in Plasma Science and Engineering — U.S. National Science Foundation · closes 2026-08-11
   Plasma science is a transdisciplinary field of research where fundamental studies in many disciplines, including plasma physics, plasma chemistry, materials science, and space science, come together to advance knowledge for discovery and te…
10. Research Training Groups in the Mathematical Sciences — U.S. National Science Foundation · closes 2026-08-11
    The long-range goal of the Research Training Groups in the Mathematical Sciences (RTG) program is to strengthen the nation's scientific competitiveness by increasing the number of well-prepared U.S. citizens, nationals, and permanent r…
11. IUSE/Professional Formation of Engineers: Revolutionizing Engineering Departments — U.S. National Science Foundation · closes 2026-09-08
    Revolutionizing Engineering Departments (hereinafter referred to as RED) is designed to build upon previous efforts in engineering education research. Specifically, previous and ongoing evaluations of the NSF Engineering Education and Cente…
12. Postdoctoral Research Fellowships in Biology — U.S. National Science Foundation · closes 2026-09-29
    The integration of Artificial Intelligence (AI) and Biological Research has the potential to pave the way for breakthroughs in biotechnology and bio-system design that will create innovations, new industries, and jobs. To capitalize on this…
13. NRL Long Range Broad Agency Announcement (BAA) for Basic and Applied Research — Naval Research Laboratory · closes 2026-09-30
    Amendment 0006The purpose of this amendment is to extend the due date for acceptance of White Papers. All other terms and conditions remain unchanged. --------------------------------------------------------------Amendment 0005The purpose o…
14. DoW Amyotrophic Lateral Sclerosis Research Program, Clinical Outcomes and Biomarkers Award — Dept. of the Army -- USAMRAA · closes 2026-09-30
    Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Clinical Outcomes and Biomarkers Award (COBA) supports the development and/or validation of clinical outcomes and biomarkers to enrich clinical tria…
15. NIDCD Clinical Research Center Grant (P50 Clinical Trial Optional) — National Institutes of Health · closes 2026-10-03
    The National Institute on Deafness and Other Communication Disorders (NIDCD) invites applications for Clinical Research Center Grants designed to advance the diagnosis, prevention, treatment, and amelioration of human sensory and communicat…

Recent Sensors & IoT SBIR winners in Colorado

1. VITAN-BIOTECH LLC (Aurora, Colorado) — Department of Health and Human Services Phase I 2023, $218,622
   Developing an integrated pipeline for routine generation of orthogonal GPCR-targeting nanobodies
2. Allander Biotechnologies (Aurora, Colorado) — Department of Health and Human Services Phase II 2023, $1,239,748
   IND-enabling toxicology studies to reach IND approval for a proprietary biologic to treat oral mucositis in cancer patie
3. CRESTONE, INC. (Boulder, Colorado) — Department of Health and Human Services Phase I 2023, $295,763
   A Novel Small Molecule Therapeutic for Acute Graft Versus Host Disease
4. BURST DIAGNOSTICS INC (Fort Collins, Colorado) — Department of Health and Human Services Phase I 2023, $279,557
   Strep-CaDI: A fast, accurate, and sensitive point-of-care test for Group A Streptococcus
5. VULINTUS, INC (Lafayette, Colorado) — Department of Health and Human Services Phase II 2023, $982,150
   SensiTrak: Automated Assessment of Forelimb Sensation
6. BOLDER BIOTECHNOLOGY INC (Boulder, Colorado) — Department of Health and Human Services Phase II 2023, $1,000,000
   Novel drug combinations for improving survival from acute radiation syndrome when administered 48 hours post- irradiatio

How to find SBIR topics: TopicScout vs alternatives

SBIR.gov is the canonical source — every SBIR/STTR topic posts there first. TopicScout's value isn't access; it's the cap-statement scoring + weekly digest so you stop scanning portals by hand. Try the free matcher against your statement — takes a paragraph, no signup.

FAQ

How do I find open SBIR topics for a Sensors & IoT company in Colorado?

The canonical source is SBIR.gov, which lists every open SBIR/STTR topic across all 11 federal agencies. To filter to Sensors & IoT-relevant topics that match your specific tech, paste your capability statement into TopicScout's free matcher — it scores all open topics against your cap statement in ~60 seconds. Colorado SBIR firms also get help from the Colorado SBDC and state matching-fund programs.

What's the best SBIR matching tool for Sensors & IoT startups?

For solo founders: TopicScout's $29/mo plan covers all 11 agencies with weekly AI-scored digests. For consulting firms supporting multiple clients: TopicScout institutional plan ($500–2k/mo flat) or HigherGov ($500–5k/yr). For nonprofits (not SBIR-eligible): Instrumentl. SBIR.gov itself is free but requires manual scanning.

Which agencies fund the most Sensors & IoT SBIR/STTR work?

Based on the current open topic list, the top agencies for Sensors & IoT are visible in the topic list above. Historically: DARPA + AFWERX + Navy SBIR for defense-adjacent Sensors & IoT, NIH + CDC for health-adjacent, NSF + DOE for foundational R&D.